Composite Diaphragm Inflation

Author: John Christopher Selby
Publisher: ProQuest
ISBN: 0549345930
Size: 14.31 MB
Format: PDF, ePub
View: 39

Normal human epidermal keratinocytes (NHEKs), like most all nucleated human cells, possess a filamentous cytoskeleton, composed of actin microfilaments (MFs), microtubules (MTs), and intermediate filaments (IFs). Distinct from connective tissues cells like the dermal fibroblast, however, keratinocytes in vivo are organized as a multicellular epithelium. In the absence of extracellular matrix for mechanical support, keratinocytes express specialized cell-cell anchoring junctions that interconnect MFs and IFs within adjacent cells in the formation of a mesoscopic network cytoarchitecture. Despite advances in our understanding of the proteins that regulate cytoskeletal filament and anchoring junction assembly, the biophysical mechanisms by which these structures provide the epidermis an innate mechanical resilience are, at present, not fully understood.

Lung Mechanics

Author: Jason H. T. Bates
Publisher: Cambridge University Press
ISBN: 9780521509602
Size: 12.78 MB
Format: PDF, ePub, Mobi
View: 59

A modern quantitative study of lung mechanics, relating mathematical modeling and engineering principles to lung function, structure, mechanics, and disease.

Mechanobiology Of Cell Cell And Cell Matrix Interactions

Author: A. Wagoner Johnson
Publisher: Springer Science & Business Media
ISBN: 1441980830
Size: 20.81 MB
Format: PDF, ePub
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Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.

Handbook Of Psychophysiology

Author: John T. Cacioppo
Publisher: Cambridge University Press
ISBN: 9781316727782
Size: 10.51 MB
Format: PDF
View: 71

The Handbook of Psychophysiology has been the authoritative resource for more than a quarter of a century. Since the third edition was published a decade ago, the field of psychophysiological science has seen significant advances, both in traditional measures such as electroencephalography, event-related brain potentials, and cardiovascular assessments, and in novel approaches and methods in behavioural epigenetics, neuroimaging, psychoneuroimmunology, psychoneuroendocrinology, neuropsychology, behavioural genetics, connectivity analyses, and non-contact sensors. At the same time, a thoroughgoing interdisciplinary focus has emerged as essential to scientific progress. Emphasizing the need for multiple measures, careful experimental design, and logical inference, the fourth edition of the Handbook provides updated and expanded coverage of approaches, methods, and analyses in the field. With state-of-the-art reviews of research in topical areas such as stress, emotion, development, language, psychopathology, and behavioural medicine, the Handbook remains the essential reference for students and scientists in the behavioural, cognitive, and biological sciences.